Insulin‐like growth factor‐1 regulates the SIRT 1‐p53 pathway in cellular senescence
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چکیده
منابع مشابه
Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence
Cellular senescence, which is known to halt proliferation of aged and stressed cells, plays a key role against cancer development and is also closely associated with organismal aging. While increased insulin-like growth factor (IGF) signaling induces cell proliferation, survival and cancer progression, disrupted IGF signaling is known to enhance longevity concomitantly with delay in aging proce...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2014
ISSN: 1474-9718,1474-9726
DOI: 10.1111/acel.12219